Search for: All records

The development of low-cost, highly efficient and stable electrocatalysts for the oxygen evolution reaction (OER) is of great significance for many promising energy storage and conversion applications, including metal–air batteries and water splitting technology. Here we report a layer-structured Ca 0.5 CoO 2 nanofibers composed of interconnected ultrathin nanoplates, synthesized using an electrospinning process. The OER activity of Ca 0.5 CoO 2 can be dramatically improved by iron doping, and the overpotential of Ca 0.5 Co 1− x Fe x O 2 ( x = 0.25) is only 346 mV at a current density of 10 mA cm −2 . The mass activity and intrinsic activity of Ca 0.5 Co 0.75 Fe 0.25 O 2 at 1.6 V are, respectively, ∼18.7 and ∼11.4 times higher than those of Ca 0.5 CoO 2 . Iron doping modifies the electronic structure of Ca 0.5 CoO 2 , resulting in partial oxidation of the surface cobalt and increased amount of highly oxidative species (O 2 2− /O 2 ). Consequently, Ca 0.5 Co 0.75 Fe 0.25 O 2 nanofibers with tuned electronic states have shown great potential as cost-effective and efficient electrocatalysts for OER. 

Using a zebrafish ionocyte model, transcriptomics and genetic analyses were performed to identify pathways and genes involved in cell quiescence‐proliferation regulation. Gene ontology and Kyoto encyclopedia of genes and genomes pathway analyses revealed that genes involved in transcription regulation, cell cycle, Foxo signalling and Wnt signalling pathway are enriched among the up‐regulated genes while those involved in ion transport, cell adhesion and oxidation–reduction are enriched among the down‐regulated genes. Among the top up‐regulated genes is FK506‐binding protein 5 (Fkbp5). Genetic deletion and pharmacological inhibition of Fkbp5 abolished ionocyte reactivation and impaired Akt signalling. Forced expression of a constitutively active form of Akt rescued the defects caused by Fkbp5 inhibition. These results uncover a key role of Fbkp5 in regulating the quiescence‐proliferation decision via Akt signalling.

 

This paper addresses a key missing piece in the current ecosystem of decentralized services and blockchain apps: the lack of decentralized, verifiable, and private search. Existing decentralized systems like Steemit, OpenBazaar, and the growing number of blockchain apps provide alternatives to existing services. And yet, they continue to rely on centralized search engines and indexers to help users access the content they seek and navigate the apps. Such centralized engines are in a perfect position to censor content and violate users’ privacy, undermining some of the key tenets behind decentralization. To remedy this, we introduce DeSearch, the first decentralized search engine that guarantees the integrity and privacy of search results for decentralized services and blockchain apps. DeSearch uses trusted hardware to build a network of workers that execute a pipeline of small search engine tasks (crawl, index, aggregate, rank, query). DeSearch then introduces a witness mechanism to make sure the completed tasks can be reused across different pipelines, and to make the final search results verifiable by end users. We implement DeSearch for two existing decentralized services that handle over 80 million records and 240 GBs of data, and show that DeSearch can scale horizontally with the number of workers and can process 128 million search queries per day. 

Abstract We present the first results from the JWST program A SPectroscopic survey of biased halos In the Reionization Era (ASPIRE). This program represents an imaging and spectroscopic survey of 25 reionization-era quasars and their environments by utilizing the unprecedented capabilities of NIRCam Wide Field Slitless Spectroscopy (WFSS) mode. ASPIRE will deliver the largest ( ∼ 280 arcmin 2 ) galaxy redshift survey at 3–4 μ m among JWST Cycle 1 programs and provide extensive legacy values for studying the formation of the earliest supermassive black holes, the assembly of galaxies, early metal enrichment, and cosmic reionization. In this first ASPIRE paper, we report the discovery of a filamentary structure traced by the luminous quasar J0305–3150 and 10 [O iii ] emitters at z = 6.6. This structure has a 3D galaxy overdensity of δ gal = 12.6 over 637 cMpc 3 , one of the most overdense structures known in the early universe, and could eventually evolve into a massive galaxy cluster. Together with existing VLT/MUSE and ALMA observations of this field, our JWST observations reveal that J0305–3150 traces a complex environment where both UV-bright and dusty galaxies are present and indicate that the early evolution of galaxies around the quasar is not simultaneous. In addition, we discovered 31 [O iii ] emitters in this field at other redshifts, 5.3 < z < 6.7, with half of them situated at z ∼ 5.4 and 6.2. This indicates that star-forming galaxies, such as [O iii ] emitters, are generally clustered at high redshifts. These discoveries demonstrate the unparalleled redshift survey capabilities of NIRCam WFSS and the potential of the full ASPIRE survey data set.